Comera Investor Presentation Deck

Identifying screening sites and desired pharmacophores. Surface Hydrophobicity Surface charge Computational studies allows 1.Identifying self interaction hotspots in mAbs 2.Identifying excipients that decrease self association 3.Identify excipients that can stabilize the mAb Identifying sites involved with Self interaction Identify single interaction site and Screen SQore library within the pocket Pharmacophore Results Name RMSD Hass Rinds 0 2 2 4 4 374 MalPort-002-964-400 0.450 Mofort-839-455-121 0.611 265 MolFort-039-455-121 9013 265 Moort-001-771-995 0.766 274 MolFort-001-771-998 0.756 276 MoPort-001-771-999 0.760 Mort-001-771-998 0.766 Port 002-771-908 0.706 MaPort-001-771-998 0.766 HaPort-001-771-998 0.756 MolFort-001-771-998 0.766 MalPort-020-138-470 0.720 MoPort-046-304-15 0.710 MuPort-002-657-242 0.739 MyPort-002-857-242 0.739 MoPort-002-857-242 0.739 342 MaPort-002-657-242 MaPort-030-230-707 342 343 MoPort-039-330-797 0.605 343 MoPort-029-230-707 9.609 343 224 114 376 342 Showing 1 to 20 of 6 h Comera LIFE SCIENCES 1 2 3 4 Next 4 4 *M 4 4 4 5 5 5 5 5 5 3 3 3 Ranked screening results 8

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