Kymera Investor Day Presentation Deck

KT-253, Unlike Small Molecule Inhibitors, Overcome the MDM2 and p53 Autoregulatory Feedback Loop Degrader Overcomes MDM2 Feedback Loop KT-253, IC90 KYMERA Oh DMSO 2h 24h 4h 24h DMSO MDM2 levels are kept at undetectable levels with MDM2 degrader KT-253, leading to p53 stabilization DS-3032, IC90 Oh DMSO 2h 24h 4h 24h DMSO MDM2 ACTB ©2021 KYMERA THERAPEUTICS, INC. MDM2 ACTB MDM2 levels are increased by the small molecule inhibitor (feedback loop), impairing p53 stabilization KYMERA R&D DAY - December 16th, 2021 p53 Inhibitor 1 MDM2 T Degrader p53 ub p53 ub ub T MDM2 p53 Degradation Feedback Loop p53 Targets PAGE 79

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