Orthofix Investor Presentation Deck

Spinal Implants: Focused Execution Innovative artificial cervical disc and comprehensive spine fixation portfolio ● ● MOTION PRESERVATION 60,000+ M6-C™ artificial cervical discs implanted over the span of 16+ years Differentiated design to mimic natural disc Future opportunity to expand market $800 million U.S. market opportunity ● ● SPINE FIXATION Comprehensive interbody offering (PEEK, PTC, 3D-Printed Titanium, and expandable) Pipeline of competitive lumbar offerings $9.0 billion global market opportunity ORTHOFIX® 8

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