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argenx SE Investor Day Presentation Deck

ARGX-117 Protects Axon Integrity While Blocking C3 Deposition in ex vivo Model ARGX-117 prevents loss of neurofilament staining at the nerve terminal and thereby preserves the integrity of the axon by blocking C3 deposition and downstream complement activation argenx C3 deposition Neurofilament Isotype control GalNACT-/-(neuronal mice) - Yao et al., Journal of Neuroscience. 2014; Mouse model - McGonigal et al., Acta Neuropathologica Communications. 2016 ARGX-117 66

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