BioAtla Investor Presentation Deck

Selective and targeted CAB technology widens therapeutic window, thus has the potential to enhance clinical outcomes in multiple tumor types సం bicatla BioAtla discovered that acidic pH at the cancer cell surface unveils binding sites that are shielded at normal pH of healthy cells BioAtla invented CAB technology, creating antibodies that bind only to these unveiled sites on cancer cells CAB binding region is not masked or caged and thus different from prodrugs that require irreversible enzymatic cleavage to become activated CAB antibodies have the potential for increased efficacy with improved safety relative to traditional antibodies Alkaline Healthy Cell Membrane Glycocalyx Basic pH BARZO 2 HEALTHY CELL Intracellular Mildly Acidic pH No CAB Binding H H REMENSE Acidic Cancer Cell Membrane CANCER CELL Intracellular Mildly Basic pH CAB Binding H+ H H H H Glycocalyx Acidic pH H H Chang, H.W., Frey, G., Liu, H., Xing, C., Steinman, L, Boyle, B.J., & Short, J.M. (2021) PNAS 118(9): 1-10, Suppl. 1-19. BioAtla| Overview 6

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