BioNTech Investor Day Presentation Deck

Understanding and exploiting immunological mechanisms APC Naive T cell CD40 MHC TCR 1 T cell 4-1BB Hochf 4 2 Pro-inflammatory cytokines 00MMUO Tumor cells PD-1 PD-L1 -Co MJCH 3 1 Treg y 4 & Antibodies B cell 1 2 3 4 mRNA-encoded cancer vaccines Shared antigens Individual antigens CAR-, TCR-, and non- engineered cell therapies Shared antigens Individual antigens Next-generation immunomodulators Dual agonist CPI + agonist mRNA-encoded effector molecules Antibodies Cytokines BIONTECH 92

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