BioAtla IPO Presentation Deck
BA3011: Encouraging Results in AXL High (TmPS 270)
Sarcoma Patients at 1.8mg/kg
Sarcoma (confirmed TmPS** 270; 1.8mg/kg Q3W or 2Q3W)
Maximum % Change from Baseline in Sum of Target Lesions
100
80
-40
-80
-100
AXL+
TmPS-90¹1
I 1.8mg/kg
d1,8
Tumor may not accurately
represent AXL. expression at
time of treatment due to
outdated age of tissue sample
AXL+
TmPS=100
1.8mg/kg
d1,8
Leiomyosarcoma Uterine I
(LMS)
LMS
TmPS-90
1.8mg/kg
LMS
(NED")
* Confirmed Partial Response (PR)
Out of 61 sarcoma patients screened
for AXL Tumor Membrane Expression:
• 35 had a TmPS ≥ 70 (57%)
AXL+
TmPS=70
1.8mg/kg
d1,8
UPS
Patient case study on right side
AXL+
TmPS-95
1.8mg/kg
d1,8
UPS
AXL+
TmPS-100
1.8mg/kg
Ewing
4 partial responses out of 6 for
sarcoma patients with TmPS
270 at the optimal dosing levels
Note: "AXL Tumor membrane Percent Score or TmPS = % Score 21+
*Tissue biopsy from resection, over 1 year old prior to trial entry
All patients: Multiple cycles of antineoplastic agents received prior to starting treatment with BA3011;
INED = No evidence of disease
bicatla
LMS Patient Case Study
Pre-treatment
Post-treatment, week 18 Scan
37% tumor reduction
. Tumor mass reduced enough to
enable successful surgical resection
resulting in NED¹
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