BioNTech Investor Day Presentation Deck

2 Variant-adapted vaccines | Omicron BA.4/5 variant-adapted vaccines increase Omicron sub-lineages/Wuhan ref. pVN 50 titer ratio in balb/c mice ● ● Ratio of variant/ Wuhan ref. pVN 50 titer Internal data. 0.1- Wuhan N=8 Balb/c mice per group Pre-immunized with 2-doses of 1 µg Booster administered on day 104 ( BA.1 BA.2 Cross-neutralization analysis BA.2.12.1 BA.4/BA.5 T162b2 on day 0 and day 21 Geometric mean ratio BNT162b2 Omi BA.4/5 b2+ Omi BA.4/5 Omi BA.1 Omi BA.2 0.21 0.09 0.10 0.08 0.42 0.59 0.50 0.50 0.35 0.46 0.55 0.35 Omi BA.2.12.1 Omi BA.4/BA.5 NUA CAR Pandemic prep. Pfizer BIONTECH 79

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