Ocuphire Pharma Investor Update

RM Mean Time to Return to Baseline PD Saving of ~4 Hours in Return to Normal PD Overall and Across Mydriatic Agents Overall Mydriatic Agent (study eye) Irides (study eye) 23 Study Eye Fellow Eye Phenylephrine Tropicamide Paremyd Dark Irides Light Irides 0 n=115 n=230 n=115 n=230 n=66 n=137 n=26 n=46 n=23 n=47 n=59 n=122 n=56 n=108 Source: MIRA-3 Table 14.2.3.2 (PP Population). 1 Placebo 1.3, p=<0.001 2.1, p=<0.001 2 2.5, p=<0.001 2.7, p=<0.001 2.3, p=<0.001 2.0, p=<0.001 ■ Nyxol 3 4 4.0, p=<0.001 5 5.6 5.7 6 6.3 6.4 Time to Return to Baseline PD (Hours) 7 Return to normal 4.2 hrs 7.1 7.0 3.9 hrs 4.3 hrs 7.6 3.6 hrs 4.4 hrs 3.4 hrs 5.0 hrs 8 Ocuphire PHARMA

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