BioNTech Investor Day Presentation Deck
Omicron BA.4/5 Monovalent and Bivalent Boosters in Mice
Substantially Increase Omicron Neutralization Responses
to all Omicron Variants Including BA.4/5 and Reference Strain
PVN 50 titer (Serum Dilution-¹)
105
104
103
10²
101
TTTT
-
Compared to Monovalent OMI BA.1, BA.4/5 neutralizing titers increase
by 11.3 fold [mono BA.4/5] or ~4.8 fold (bivalent BA.4/5)
4150
Wuhan
018
3490 1131 617 436
BA.1 BA.2 BA. BA.4/5
2.12.1
9870 4150 5869 4935 4935
Wuhan BA.1 BA.2 BA. BA.4/5
2.12.1
OMI BA.1
OMI BA.4/5
N=8 mice Balb/c mice. Mice preim munized with 2 doses of BNT162b2; boosters given at day 104
Pseudovirus neutralization assay; LOD, Limit of Detection
4H
W
LOD
5869 2075 2691 3200 2075 GMT
Wuhan BA.1 BA.2 BA. BA.4/5
2.12.1
BNT162b2 + OMI BA.4/5
BU-875View entire presentation