BioNTech Investor Day Presentation Deck

Fix Vac | BNT111 - Long duration of clinical responses observed for patients receiving BNT111 monotherapy and combination with CPIs ¹ Growth kinetics of Target lesions Change from baseline in target lesion (%) 80 60 40 20 0 -20 -40 -60 -80 -100 -100 0 100 200 300 400 500 600 800 700 Days since first vaccination 900 1000 1100 Data cut-off: May 24, 2021. 1 One patient in the BNT111 monotherapy group who achieved a CR is not shown as only non-measurable target lesions were present (which later disappeared). CPI, checkpoint inhibitor; CR, complete response O 1200 1300 1400 Maximal Dose 14,4 29 50 75 100 Shape by: Treatment MONOTHERAPY CPI NUM BRAF/MEK mRNA cancer vaccines BIONTECH 110

View entire presentation