Certara Investor Day Presentation Deck

Tale of two COVID-19 repurposed therapies Odds-ratio for death 3.0 2.5 2.0 1.5 1.0 0.5 0.0 200 Learning on Anti-Interleukin-6 (95% CI in green) 300 400 Pandemic Day 500 600 RWS RCT 14000 12000 10000 8000 cumulative sample size 6000 4000 2000 0 Odds-ratio for death 3.0 2.5 2.0 1.5 1.0 0.5 0.0 Learning on Glucocorticoids (critical/severe patients) T + 200 300 (95% CI in blue) 400 Pandemic Day 500 68 600 For new drugs to be commercially successful, they must differentiate themselves from the standard of care. Model-based meta-analysis using CODEX can help predict how a new drug's safety and efficacy profile might compare to competitor drugs, informing critical go/no-go decisions. RWS RCT CERTARA

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