Investor Presentation

23 Distribution of CRISS Scores and Change in mRSS at Month 18 OLE mRSS 5 0 -5 -10 -15 -20 -25 -30 -35 II CHANGE IN mRSS Each bar represents an individual subject, Week 52 87% of subjects had ≥ 5 point reduction in mRSS CRISS 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% CRISS Scores Lenabasum Each bar represents an individual subject, Week 72 50% of subjects achieved CRISS score 100%

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