Certara Investor Presentation Deck

Reconciliation of Net Income (Loss) to Adjusted Net Income (Loss) Net income(a) Currency gain (loss)(a) Equity-based compensation expense(b) Amortization of acquisition-related intangible assets (c) Acquisition-related expenses(d) Transaction-related expenses(e) Loss on disposal of fixed assets(f) First-year Sarbanes-Oxley implementation costs (8) Income tax expense impact of adjustments(h) Adjusted Net Income © Copyright 2022 Certara, Inc. All rights reserved. THREE MONTHS ENDED MARCH 31 2021 $ 2022 (in thousands) 2,210 $ (705) 7,513 10,880 272 17 5 653 (3,916) 16,929 28 $ 1,052 191 5,151 8,428 1,596 685 107 (2,786) 14,424 CERTARA

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