Bionomics IPO Presentation Deck

Mechanistic Validation of BNC210 as Evidenced by EEG Response BNC210 blood-brain barrier penetration and nicotinic receptor target engagement in humans Bionomics Power in alpha2 band BNC210 Reduced Nicotine-induced EEG Responses EEG Electroencephotography ** p-value less than 0.01 1.5. 1.0- 0.5- 0.0 0.0 ACHR=Nicotini Acetylcholine Receptor Day -1 without BNC210 Day 7 with BNC210 NS 0.5 p=0.0062 1.0 Nicotine (mg) p=0.0026 1.5 p=0.0487 2.0 Activation of nicotinic receptors in the brain induces EEG response x432 and a7 receptors are the major nACHR populations targeted BNC210 daily oral dosing reduced nicotine-induced EEG in the a 2 band Observed reduction in EEG response, potentially due to BNC210's negative allosteric modulation of the a7 receptors 36

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