Taysha IPO Presentation Deck

Vagus nerve delivery platform may enable AAV9 redosing The vagus nerve represents the main component of the parasympathetic nervous system (PNS) Direct delivery to the vagus nerve will provide broad coverage of the PNS and enable redosing by subverting the humoral immune response Proof of concept established in rodent and dog models Confirmatory studies in NHPs will be conducted 2H20, if successful, platform will be utilized to facilitate redosing of previously treated patients in the Giant Axonal Neuropathy AAV9 clinical trial¹ Parasympathetic System Nerve i Nerve V Nerve Nerve X (Vogus) Pelvic splanchnic nerves Constricts pupils Stimulates flow of saliva Constricts bronchi Slows Heartbeat Stimulates peristalsis and secretion Stimulates Bile Release GH CHE Stimulates vasodilation Contracts bladder Taysha has exclusive rights to the vagus nerve redosing platform in select indications. Hannah's Hope Foundation owns the rights to the Giant Axonal Neuropathy program. 47

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