Equillium Results Presentation Deck

Treatment Goals for Lupus Nephritis The goal of therapeutic intervention is to rapidly and deeply reduce urine protein creatinine ratio (UPCR) and reduce steroid administration, noting that patients in the nephrotic range (> 3-3.5 g/d) may take an additional 6-12 months to achieve desired outcomes, due to slower proteinuria recovery equillium Target proteinuria decrease of: At least 25% EULAR/ERA-EDTA 2019 LN Guidelines by 3 months At least 50% Partial clinical response by 6 months UPCR below 0.5- 0.7 g/g Complete clinical response by 12 months Reduce steroids to: <7.5 mg/day by 3 to 6 months Fanouriakis A, et al., Ann Rheum Dis., 2020: Eular/ERA-EDTA European League Against Rheumatism/European Renal Association-European Dialysis and Transplant Association 7

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