BioNTech Investor Day Presentation Deck

2 Variant-adapted vaccines I SARS-CoV-2 epidemiology changes quickly: Vaccine updates need to adapt with the pace of the virus Variant vaccine update pathway Clinical (current) ~8 months Pre-clinical/CMC (proposed) ~3 months Proportion of Strains 100 75 50 25 0 Delta Omicron BA.1 Omicron BA.2 Omicron BA.2.12.1 Omicron BA.4 Omicron BA.5 GISAID Initiative database: https://www.gisaid.org/ (accessed June 20, 2022). Dec 2021 Feb 2022 Omicron Wave Circulating Strains Apr 2022 Sampling Date USA Jun 2022 NUA CAR Pandemic prep. Pfizer BIONTECH 73

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