Taysha IPO Presentation Deck

GM2 accumulation was significantly reduced in the mid-section of the brain following treatment with TSHA-101 after 16 weeks GM2 / GD1a N Treatment Type Heterozygote/Vehicle (n=6) Knockout/2.5x10¹¹ total vg (n=11) Knockout/1.25x10¹¹ total vg (n=6) Knockout/0.625x10¹¹ total vg (n=6) Knockout/Vehicle (n=6) **** p-value<0.0001 * p-value=0.0179, 0.0295 * 21

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