Orthofix Investor Presentation Deck

Expected Significant Growth & Value Creation $ millions Revenue (1) Revenue Growth CAGR (2) Gross Margin Adjusted EBITDA Margin ● ● ORTHOFIX® Sea Spine 1) 2) Year 3 4) -$1,000 Well-financed with >$125 million of liquidity expected at closing (4) Expect to grow into existing $300 million credit facility over time Double-digits >70% Mid-teens Excludes net revenue synergies Estimated compound annual revenue growth rate from 2022 to 2025 Excludes stock-based compensation savings Cash + immediate availability under credit facility Revenue Growth Complementary portfolios to drive projected double- digit growth post-integration period Significant Cost Synergies Leveraging combined infrastructures expected to generate $40M (3) in annualized cost savings by year three Adj. EBITDA & Adj. ROIC Accretive Adj. EBITDA expected to be accretive to Orthofix in the second year & Adj. ROIC accretive after fully realizing synergies Fully-Funded Organic growth funded through existing Orthofix and SeaSpine cash, the existing Orthofix Credit Facility, and free cash flow positive after fully realizing synergies 7

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