Investor Presentation

TRANSFORMING TOBACCO WITH VLNⓇ 60% of adult smokers indicate a likelihood to use VLN® based on perception studies¹. Discernable Adult Smoker Benefits 2,3 ▪ Reduced nicotine exposure and dependence ▪ Fewer cigarettes smoked per day ■ Reduced withdrawal symptoms ▪ Minimal or no compensatory smoking ▪ Increased number of smoke-free days Quit attempts doubled No increase in adverse effects in persons with mental health disorders ■ ■ VLN® is a UNIQUE 95% REDUCED NICOTINE CONTENT combustible cigarette alternative unlike any tobacco product available in the market today. What is VLNⓇ? How VLN® Helps Adult Smokers Science-Backed Research from Clinical Trials ■ ■ ■ 22ND CENTURY GROUP Proprietary, combustible cigarette made with tobacco that contains 95% less nicotine than conventional cigarette alternatives Familiar combustible product format that replicates the conventional cigarette experience including the sensory and experiential elements of taste, scent, smell, and "hand-to-mouth" behavior VLN® contains 0.5 mg of nicotine per gram of tobacco, an amount cited by FDA, based on clinical studies, to be "minimally or non-addictive". Lack of reward from nicotine creates a dissociation between the act of smoking and nicotine which helps adult smokers reduce the harm caused by smoking Since 2011, 22nd Century's reduced nicotine content cigarettes has been used in more than 50 independent scientific clinical studies conducted by universities and institutions. ▪ Studies have been largely funded by U.S. government agencies and are estimated to have cost over $100M 1. Based on consumer perception studies conducted by 22nd Century Group. 2. Eric C. Donny, Ph.D., Rachel L. Denlinger, B.S., et al. "Randomized Trial of Reduced-Nicotine Standards for Cigarettes." Oct. 2015. 3. Dorothy K. Hatsukami, PhD; Xianghua Luo, PhD, et al., "Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure." Sept. 2018. 5

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