3Q22 Investor Update

■ REGULATORY ENVIRONMENT FAVORS VLNⓇ ■ FDA continues to advance its proposed menthol ban and reduced nicotine content mandate. ▪ State and local governments are taking direct action. VLN® Menthol King cigarettes could be the only combustible menthol cigarette on the market exempt from the menthol ban. The science shows a reduced nicotine mandate would help all smokers more easily quit smoking or migrate to less toxic products. 22nd Century's research cigarettes continue to fuel numerous independent scientific studies to validate the enormous public health benefit identified by the FDA from implementing a nicotine standard. VLN MENTHOI VLN 95% LESS NICOTINI Nicotine is addictive. Less nicotine does NOT mean safer. All cigarettes can cause disease and death Ž 22ND CENTURY GROUP HELPS YOU SMOKE LESS VLN 95% LESS NICOTINE Nicotine is addictive. nice does NOT mean

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