Taysha IPO Presentation Deck

Preliminary animal studies demonstrated the utility of GYS reduction Survival (%) 100- 50- WT Gys14 Gbe1ysys Gys1 Gbe1ywys 10 Age (months) 20 Genetic knockdown of GYS1 results in dramatic increase in survival Rescue of APBD mice achieved with 50% reduction in glycogen synthase activity Normalization in body mass observed in male and female APBD mice Disease progression-associated decline in body mass Male body mass (g) 40 30 Female body mass (g) 2 30- 20 7 Age (months) Age (months) 57

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