Kymera Results Presentation Deck

Included as Exploratory Endpoints Skin lesions and global assessments performed on Days 1, 14, 28, 35 and 42 Symptom scores performed at additional time points ● AD ● ● HS ● ● Clinical Endpoints Change from baseline in Eczema Area and Severity Index (EASI) Peak pruritus NRS Investigator Global Assessment (VIGA-AD) Additional ad hoc analysis included: Peak Pruritus NRS Response (≥4-point improvement from baseline) Change from baseline in Total Abscess and Inflammatory Nodule (AN) count Skin pain Numerical Rating Scale (NRS) Peak pruritus NRS HS-Physician's Global Assessment (HS-PGA) Additional ad hoc analyses included: ANO/1/2 Response, HiSCR50, HiSCR75, and Pain NRS30 KYMERA ©2022 KYMERA THERAPEUTICS, INC. PAGE 44

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