Talkspace SPAC Presentation Deck

t Science-based approach driving meaningful clinical outcomes Clinical case study Talkspace treatment efficacy 12 10 8 6 4 2 0 T . Pre ● ■PHQ-9 T ■GAD-7 Talkspace treatment efficacy Published study of 10,718 participants Study length of 1.5-3 months T 68% of patients improved or remitted Post T Average patient age 35 Based on PHQ-9, GAD-7 results Clinical standard for measuring depression and anxiety symptoms, respectively A focus on clinical excellence 10 Peer-reviewed studies DOI: 10.1002/jclp.22718 RESEARCH ARTICLE Patterns of utilization and a case illustration of an interactive text-based psychotherapy delivery system George C. Nitzburg¹,2 Barry A. Farber¹ JOURNAL OF MEDICAL INTERNET RESEARCH Original Paper ● WILEY Message Delivery for the Treatment of Posttraumatic Stress Disorder: Longitudinal Observational Study of Symptom Trajectories Matteo Malgaroli", PhD; Thomas Derrick Hull23*, MS; Shannon Wiltsey S Two-way messaging therapy for depression and anxiety: longitudinal response trajectories Thomas D. Hull¹¹, Matteo Malgaroli, Philippa S. Connolly, Seth Feuerstein and Naomi M. Simon² BMC Psychiatry Open Access Check for updates Identifying therapist conversational actions across diverse psychotherapeutic approaches Fei-Tzin Lee*, Derrick Hull, Jacob Levine¹, Bonnie Ray, Kathleen McKeown* "Columbia University, Department of Computer Science Talkspace Additional 2020 NIMH grants • $3.9M grant with University of Washington to conduct a randomized control trial evaluating the efficacy of messaging therapy Source: Hull, T.D., Malgaroli, M., Connolly, P.S. et al. Two-way messaging therapy for depression and anxiety: longitudinal response trajectories. BMC Psychiatry 20, 297 (2020) $3.7M grant with University of Washington that examines strategies for enhancing digital behavioral health care 46

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