23andMe Investor Day Presentation Deck
23ME'610 Shows Broader Enhancement of Proinflammatory
Cytokine Secretion than Anti-PD1
●
Mixed immune cell assay that stimulates T cells
with MHCII binding bacterial super antigen
SEB
23ME'610
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Cancer patient-derived PBMCs
PBMCs: Peripheral Blood Mononuclear Cell (T cells, B Cells, NK Cells, Monocytes)
SEB: Staphylococcal Enterotoxin B (bacterial super antigen)
23ME'610 Increases Interferon-gamma Secretion
from SEB-Stimulated Cancer Patient PBMCs
to Control
Fold Change Relative
1923 (Endometrial)
4195 (Ovarian)
9203 (Endometrial)
Interferon-y
0824 (Lung)
7181 (Melanoma)
2019 (Pancreatic)
0818 (Prostate)
23ME '610
Isotype Control
anti-PD-1
5011 (Endometrial)
0910 (Colorectal)
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*, p < 0.05
Interferon-gamma is a pro-inflammatory cytokine that is secreted by activated T cells
23ME '610 increases interferon-gamma secretion from SEB-stimulated cancer patient PBMCs compared to the isotype
control antibody and anti-PD-1 in the majority of tumor samples tested
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