BioNTech Results Presentation Deck
RiboCytokines: A Tailored Approach to T Cell Regulation and Stimulation
IL-2 supports differentiation, proliferation,
survival and effector functions of T cells
mRNA encoding sequence-modified IL-2 variant.
Sequence modification that weakens binding to IL-2Ra
(CD25)
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BNT151
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Designed to stimulate naïve and effector T cells with low to
no expression of IL-2Ra (CD25low/neg)
Stimulates anti-tumor effector cells without extensively
triggering immunosuppressive regulatory T cells
Combination with anti-PD-1/PD-L1 therapy
IL-2, interleukin-2; IL-7, interleukin-7; IL-2Ra, interleukin-2 receptor alpha subunit.
↑ T cell proliferation
↑ T cell survival
BNT152 (IL-7)
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mRNAs encoding IL-2 and IL-7
BNT153 (IL-2)
Stimulates recently activated anti-tumor T cells and
regulatory T cells
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↑ T cell effector function
BNT152 153
Sensitizes effector T cells to IL2
Controls fraction of immunosuppressive regulatory T cells
Combination with RNA vaccineView entire presentation