BioNTech Results Presentation Deck slide image

BioNTech Results Presentation Deck

RiboCytokines: A Tailored Approach to T Cell Regulation and Stimulation IL-2 supports differentiation, proliferation, survival and effector functions of T cells mRNA encoding sequence-modified IL-2 variant. Sequence modification that weakens binding to IL-2Ra (CD25) ● ● ● BNT151 32 Designed to stimulate naïve and effector T cells with low to no expression of IL-2Ra (CD25low/neg) Stimulates anti-tumor effector cells without extensively triggering immunosuppressive regulatory T cells Combination with anti-PD-1/PD-L1 therapy IL-2, interleukin-2; IL-7, interleukin-7; IL-2Ra, interleukin-2 receptor alpha subunit. ↑ T cell proliferation ↑ T cell survival BNT152 (IL-7) ● mRNAs encoding IL-2 and IL-7 BNT153 (IL-2) Stimulates recently activated anti-tumor T cells and regulatory T cells ● ↑ T cell effector function BNT152 153 Sensitizes effector T cells to IL2 Controls fraction of immunosuppressive regulatory T cells Combination with RNA vaccine
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