Bionomics Investor Presentation Deck

Mechanistic Validation of BNC210 as Evidenced by EEG Response BNC210 blood-brain barrier penetration and nicotinic receptor target engagement in humans Bionomics Power in alpha2 band ** BNC210 Reduced Nicotine-induced EEG Responses 1.5 1.0- 0.5- 0.0 0.0 nAChR=Nicotinic Acetylcholine Receptor EEG Electroencephalography p-value less than 0.05 p-value less than 0.01 M Day -1 without BNC210 Day 7 with BNC210 NS 0.5 ** p=0.0062 1.0 Nicotine (mg) ** p=0.0026 1.5 p=0.0487 2.0 Activation of nicotinic receptors in the brain induces EEG response a432 and a 7 receptors are the major nACHR populations targeted BNC210 daily oral dosing reduced nicotine-induced EEG in the a2 band Observed reduction in EEG response due to BNC210's negative allosteric modulation of the a 7 receptors 31

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