2024 JP Morgan Healthcare Conference
●
BRUKER - AN EMERGING LEADER OF THE POST-GENOMIC ERA
timsTOF Platform Advancing 4D-Proteomics
→ Unmatched Robustness (~60 SPD-200 SPD)
Unparalleled Duty Cycle (PASEF, diaPASEF, prmPASEF, capsPASEF)
* High-Throughput Omics (5min, 20min methods)
* Identify more PTMs (Mobility Offset Mass Aligned - MOMA)
Higher Confidence ID with CCS values (TIMScore, CCS-Predict, AI/DL)
→ Single Cell Proteomics (Deep Visual, MALDI-Guided, LCM spatial)
timsTOF Platform:
Unbiased Discovery and Quant at
depth and scale with 1% FDR
(without antigen cross-reactivity)
Update end of FY 2023:
Installed base >800 units
timsTOF Ultra introduced
2022 Bruker
timsTOF Pro 2
Ultimate
Workhorse
16,000
14,000
12,000-
10,000
8000
6000-
4000-
2000
0
timsTOF HT
Ultimate Workhorse
Extended Range
diaPASEF, diaNN 1.8 SwissProt predicted library
7
ng K562 digest on column
1200
1400
TOFU
2000
Launched
June 2023
Precursors Identified
stripped sq
Proteins Identified
timsTOF Ultra
Ultimate
Sensitivity
Innovation with Integrity |
BRUKER
timsTOF HT:
More than 100,000
unique peptides
identified with
60-minute nLC
gradient using
dia-PASEF method
timsTOF flex
Ultimate
Flexibility
January 8, 2024
I
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