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Lower-Risk MDS Patient Experience B Diagnosis Median age ~70 years Symptomatic Anemia geron Increasing Transfusion Dependence Lengthy Office Visits High-Cost Burden Symptomatic anemia and transfusion dependence are key drivers of patient burden and poor quality of life Poor Quality of Life Higher Risk of Progression to AML DRG MDS Landscape & Forecast 2022, Mangaonkar, et al., Blood Cancer Journal 2018; Giagounidis, et al. Clinical Cancer Research 2016; Incidence and Outcomes for Low Risk MDS, ASH 2012; Greenberg et al, Blood 2012; Feneaux et al, JCO 2017; Platzbecker et al, Blood 2019; Cogle et al, Curr Hematol Malig Rep 2015; Greenberg et al Blood 1997; Greenberg et al, Blood 1997. Shortened Survival 7

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