Ocuphire Pharma Investor Updates

P 11 Patient Population - Subject Disposition Per Protocol Population, mITT, And Safety Population Are Essentially Identical ● • ● All Randomized Population (ARP) Safety Population (SP) Modified Intention to Treat Population (mITT) Per Protocol Population (PP) Completed Study Discontinued Study Early Placebo Alone N (%) 45 Source: VEGA-1 TLR Table 14.1.1 Subject Disposition 45 (100%) 44 (98%) 43 (96%) 44 (98%) 1 (2%) Nyxol Alone N (%) 30 30 (100%) 30 (100%) 30 (100%) 30 (100%) 0 LDP Alone N (%) 31 31 (100%) 31 (100%) 31 (100%) 31 (100%) 0 Nyxol+LDP N (%) 44 44 (100%) 43 (98%) 43 (98%) 43 (98%) 1 (2%) Total N (%) 150 150 (100%) 148 (99%) 147 (98%) 148 (99%) 2 (1%) 148/150 subjects completed the study (mITT) Only a single subject difference between mITT and PP population Per Statistical Analysis Plan, all analyses performed on PP population with results being nearly identical for mITT Ocuphire PHARMA

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