Absci Investor Presentation Deck
NON-STANDARD AMINO ACID INCORPORATION
Bionic™ protein technology:
non-standard amino acid (nsAA) incorporation
Absci's high-yielding Bionic SoluPro™ strain enables
selective site-specific nsAA incorporation into
difficult-to-produce biologics (proteins, enzymes,
mAbs, fabs, VHHs)
Bionic™ protein technology enables:
Rapid assessment of payload location
• Precise control over payload location
• Uniform and homogenous Drug-Antibody-Ratio
(DAR) for ADCs
• Attachment of diverse chemical moieties for
novel applications
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ABSCI CORPORATION 2023 ALL RIGHTS RESERVED
EXPRESSION OF MAB IN BIONIC SOLUPRO"
CELL LINE (ADC PRECURSOR)
mAb
000
nsAA
Bionic SoluPro™
strain & process
pAcF - p-acetyl-phenylalanine
pAzF - p-azido-L-phenylalanine
oPrY -o-propargyl-L-tyrosine
ADC precursor mAb
TM
absci. 35View entire presentation