Context Therapeutics Investor Presentation Deck
Many CLDN Proteins are Associated with Disease
CLDN
CLDN 1
CLDN 2
CLDN 3
CLDN 4
CLDN 5
CLDN 6
CLDN 7
CLDN 9
CLDN 11
CLDN 14
CLDN 15
CLDN 16
CLDN 17
CLDN 18.2
CLDN 19
Disease
Colitis, skin permeability
Colorectal cancer, IBD
Psoriasis, ovarian cancer
Diabetes, ovarian cancer
Cerebral edema, depression
Multiple cancers
Colon cancer
Hearing loss
Myelin dysfunction
Kidney stones, hearing loss
Celiac disease
Hypercalcinuria
Renal dysfunction
Gastric cancer
Renal dysfunction, vision loss
15 Context Therapeutics Inc. - Sept. 2022
Reference
Bhat 2016, Furuse 2001
Barrett 2020, Dhawan 2011
Sikora 2019, Oh 2021
Li 2014, Stewart 2006
Menard 2017, Matsumoto-Okazaki 2012
Antonelli 2011, Reinhard 2020, Ushiku 2012
Xu 2021
Nakano 2009, Ramzan 2021
Maheras 2018, Riedhammer 2021
Thorleifsson 2009, Wilcox 2001
Schumann 2012
Simon 1999
Adil 2022
Nimi 2001
Adil 2022, Wang 2019
CLDN6xCD3 Bispecific Antibody Program
Human CLDN Family Tree
CLDN6 shares significant homology with CLDN3, 4, 9.
CLDN9
CLDN6
CLDN4
CLDN3
CLDN5
CLDN8
CLDN17
CLDN2
CLDN14
CLDN20
CLDN7
CLDN1
CLDN19
CLDN34
CLDN12
CLDN23
CLDN16
CLDN24
CLDN22
CLDN25
CLDN18
CLDN11
CLDN15
CLDN10View entire presentation