Kymera IPO Presentation Deck

KYMERA E3 Ligase Whole-Body Atlas Toolbox Ternary Complex System Pharmacology Model Proprietary Chemistry Pegasus E3 Ligase Whole-Body Atlas Focused on determining the expression profiles of "600 unique E3 ligases • Patterns mapped in both disease and healthy contexts . Ability to match a target protein with appropriate E3 ligase based on expression, and biology - Vision to develop tissue selective or tissue restricted degraders to enable novel therapeutics opportunities E3 LIGASES TARGETS CRBN CULAA DDB1 XIAP LIGASE 1 LIGASE 2 LIGASE 3 LIGASE 4 O RNF114 (MOA) IN YOU DCAF16 LIGASE S LIGASE 6 LIGASE T LIGASE B LIGASE 9 LIGASE TO STATS IRAKA TARGET 1 TARGET 2 TARGET: Abundand 000000000 00000 TONSIL LIVER SPLEEN STOMACH BRAIN LUNG TESTIS TISSUES DUODENUM SMALL INTESTINE URINARY BLADDER HEART ESOPHAGUS THYROID GALL BLADDER ENDOMETRIUM COLON KIDNEY FALLOPIAN TUBE SMOOTH MUSCLE PROSTATE APPENDIX PANCREAS OVARY RECTUM PLACENTA ADIPOSE TISSUE BO HAWAT SALIVARY GLAND ADRENAL GLAND UNDISCLOSED Ubiquitous Restrictive Selective

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