Certara Investor Presentation Deck

Notes to Reconciliations (a) Represents amounts as determined under GAAP. (b) Represents expense related to equity-based compensation. Equity-based compensation has been, and will continue to be for the foreseeable future, a recurring expense in our business and an important part of our compensation strategy. (c) Represents amortization costs associated with acquired intangible assets in connection with business acquisitions. (d) Represents costs associated with mergers and acquisitions and any retention bonuses pursuant to the acquisitions. (e) Represents costs associated with our public offerings that are not capitalized. (f) Represents the gain/loss related to disposal of fixed assets. (g) Represents the first-year Sarbanes-Oxley costs for accounting and consulting fees related to the Company's preparation to comply with Section 404 of the Sarbanes-Oxley Act in 2021. (h) Represents the income tax effect of the non-GAAP adjustments calculated using the applicable statutory rate by jurisdiction. (i) Represents potentially dilutive shares that were excluded from the Company's GAAP diluted weighted average common shares outstanding because the Company had a reported net loss and therefore including these shares would have been anti-dilutive. © Copyright 2022 Certara, Inc. All rights reserved. 30 CERTARA

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