Akouos IPO Presentation Deck

A Single Dose of AK-OTOF Restored Cochlear Function in Mature Mice Lacking Otoferlin 30 Click Level (dB SPL) 100 90 80 70 60 50 Wild-Type Vehicle Control 40 www Time re Click Onset (msec) Otoferlin KO + Vehicle Control Click Level (dB SPL) 100 90 80 70 60 50 40 Time re Click Onset (msec) CONFIDENTIAL Otoferlin KO + AAVAnc80-hOTOF Click Level (dB SPL) 100 90 80 70 50 40 www www www است www. Time re Click Onset (msec) In a preclinical study, a single dose of AK-OTOF restored cochlear function in mice lacking otoferlin AKOUOS

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