Kymera Investor Day Presentation Deck

Substantial IRAK4 Degradation in Skin Observed in Dermis and Epidermis IRAK4 = Red KYMERA Predose DAPI/IRAK4 DAPIIRAK4/panCK Pan cytokeratin (panCK) is used as the epidermal marker Day 14 ©2021 KYMERA THERAPEUTICS, INC. Representative images from subject in 50 mg cohort Day 28 (recovery) KYMERA R&D DAY - December 16th, 2021 PAGE 39

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