Centessa IPO Presentation Deck

SerpinPC: Complete Correction of Mouse Hemophilia Phenotype Target Protease SerpinPC is the Serpin: alpha-1-antitrypsin COMPLETE RESCUE OF HA MICE BY PROLONGED EXPOSURE SerpinPC administered subcutaneously every other day prevented death of HA mice from spontaneous internal bleeding Pre-treatment with SerpinPC 12 hours before tail Mice Alive transection reduced blood loss in HA mice in a dose- dependent manner 10- 8- Bleeding Volume (ul) 6- 2- 800- €700+ 600 500+ 400- 300- 200 100- Survival SINGLE DOSE RESTORED NORMAL BLEEDING IN HEMOPHILIA MICE Vehicle 0+ 0 0.01 mg/kg 0- 0 5 10 15 20 25 30 35 40 45 50 55 60 Day Untreated HA Blood Loss 1 mg/kg 0.1 mg/kg Wild-type Blood Loss 5 SerpinPC dose (mg/kg) 10 Apcintex CENTESSA 19

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