BioNTech Investor Day Presentation Deck

1 Neoantigen prediction Individualized targets: Not all neoantigens are created equal Neoantigen selection process -Tumor HLA typing Unique patient WES ↓ XX Germline Somatic mutation ID Expression on malignant tissue. Epitope prediction Yadav M, et al. Nature 2014; 515:572-576. Quantifying mutant epitope characteristics to rank immunogenicity Will the mutant peptide be presented on the antigen-presenting cell surface? Will T cells recognize the mutant peptide? Candidate tumor neoantigen(s) 28,439 4,285 1,290 170 7 2 3 Digital & AI/ML Is the mutation expressed in the tumor, but not in normal tissues? Is the mutation clonal? Exome variations Exome coding variations Transcript coding variations Predicted neo-epitopes Spectra-identified neo-epitopes Predicted immunogenic neo-epitopes Validated immunogenic neo-epitopes Target selection ranked list Target rank #1 Target rank #2 Target rank #20 BIONTECH 40

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