ATAI Investor Day Presentation Deck

Neuromodulator discovered in vivo, pharmacologically defined using electrophysiology atai LIFE SCIENCES RL - 007 enhances basal neuronal signaling, glutamatergic synaptic transmission, and long- term potentiation (LTP) ✓ Discovered through an in vivo phenotypic screen ✓ Enhances basal glutamatergic tone, enhances LTP, and synergizes with ACHEIS ✓ In Vivo behavioral effects are blocked by GABAB and nACHR antagonists fEPSP slope (% of baseline) 240 fEPSP Ampl. (% Change from BL) 200- 160- 120- 80- 40 19 14 -1 0 O O O O ACSF 1 nM ** 10 nM 100 nM ** 1000 nM Veh. T 20 TBS RL-007 40 minutes Physo. P<0.005 * 007 ** 60 *: p< 0.001 P<0.04 80 007+ Physo. 126

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