BenevolentAI Investor Conference Presentation Deck

DEMO Target Triage Overview Literature Biological Rationale ♡ Ligandability Safety Tissue Expression O Therapeutic Evidence Ⓒ Druggability Publication View paper September 2005 View paper December 2021 View paper January 2021 Rank 1 2 ✰ Programs ALS demo Oxidative stress in ALS ALS demo / prostaglandin-endoperoxide synthase 2 3 Back to the list. PTGS2 3 Match Absent on other lists i Overview Literature Biological Rationale Query 1 PTGS2 is a promising novel therapeutic target to decrease response to oxidative stress in amyotrophic lateral sclerosis. Top 100 sentences found in 70 unique publications. Top Enterprise score is 0.771 Enterprise score i ●0.771 0.726 Ⓒ 0.698 Where in publication text text Literature Enterprise Evidence Literature evidence relevant to the biological question according to the Enterprise model. Enterprise uses the name of the target and the components of the biological question to form a set of sentence-like queries. The model then finds and scores sentences from publications that are similar to each query, based on its understanding of the literature. text Query 1 PTGS2 is a promising novel therapeutic target to decrease response to oxidative stress in amyotrophic lateral sclerosis. Top 100 sentences found in 70 unique publications. Top Enterprise score is 0.771 Publication Rank Enterprise score Sentence from publication Where in nuhlication Sentence from publication Thus, COX-2 could play a partial role in neuronal damage, as suppression of its activity offers an incomplete neuroprotective effect in a mouse model of SOD1 related ALS. Was this helpful? 1 41 Therefore, the role of Cox-2, which is upregulated by SP1, in the oxidative stress state of neurons and glial cells. during the onset of ischemic stroke needs to be further explored. Was this helpful? 1 41 Neurotoxicity via elevating COX-2 expression was noted in neurodegenerative diseases, such as multiple sclerosis, amyotrophic lateral sclerosis, and Parkinson and Alzheimer diseases; meanwhile, the inhibition of COX 2 overossion promoted neuroprotective offorts according to coveral ovnorimonto 1.26 27 201 mplete 1641 glial cells 1641 tiple ion of 1641 eath in >>> 1 E Til

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