Kymera IPO Presentation Deck
KYMERA
E3 Ligase
Whole-Body
E3 Ligase
Binders
Toolbox
Ternary
Complex
Modeling
Quantitative
System
Pharmacology
Proprietary
Chemistry
H
H
1
V Pegasus
E3 Ligase Binders Toolbox
E3 Ligase Whole Body Atlas
queried to identify a tissue
sparing E3 ligase based on target
protein unwanted pharmacology
(i.e. bone marrow for a particular
target of interest)
A Bone marrow sparing E3 ligase
identified
Screening and optimization lead
to a novel binder to a previously
unliganded E3 ligase (E3 ligase
binders toolbox)
A novel degrader based on a
bone marrow sparing E3 ligase
demonstrated target degradation
This E3 Ligase is Not Expressed in Bone Marrow
Concentration (M)
400-
100
% Target
150
Ligand Identification
TPD with Bone Marrow Sparing Novel E3 Ligase
75-
50
10
Cereblon
A
Novel E3
H
Log Compound) (M)
Bone marrow: CD34+
from five donors
5
Target Target Protein
DC (M)
DTH: (8)View entire presentation