Ocuphire Pharma Investor Update

RM 19 Comparison of One Drop (Fellow Eye) with Two Drops (Study Eye) Similar 52% of Subjects Return to Baseline at 90 Minutes with a Single Drop of Nyxol Percent of Subjects (%) 100% 80% 60% 40% 20% 0% 4% 4% 0.5 5% Percent of Subjects Returning to ≤ 0.2 mm of Baseline PD Fellow Eye (mITT) p<0.0001 28% 1 5% MIRA-3 Phase 3 Trial p<0.0001 52% 1.5 7% p<0.0001 65% p<0.0001 2 15% 75% p<0.0001 Source: MIRA-3 Table 14.2.1.1 (mITT). Data includes all three mydriatics (Phenylephrine, Tropicamide, Paremyd). 11% 84% 3 Time Post-Treatment with Nyxol/Placebo (Hours) Placebo (n=124) ■Nyxol (n=244) p<0.0001 31% 90% p<0.0001 65% 91% 24 Ocuphire PHARMA

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