Taysha IPO Presentation Deck

SURF1-related Leigh syndrome is an early onset neurodegenerative disorder - Deficiency in the SURF1 gene results in mitochondrial dysfunction and dysregulation of oxidative phosphorylation SURF1 mutations are implicated in Leigh syndrome as well as Charcot-Marie Tooth 4K Symptoms appear in late infancy and include episodic neurological regression, movement disorder, and respiratory failure - The estimated prevalence of SURF1 is 300 patients in the US and EU AAV9+ IXT hSURF1+ Intrathecal delivery ISIOON TAITOIN SURFI PET100 SUCLA MTFMT Age of onset t Age of death Age at last report Age of onset C Age of death last report Age of onset HD Age of death Age at last report Age of onset Age of death Age at last report Age of onset Age of death Age at last report Age of onset Age of death Age at last report * 102 244 215 22 241 212 264 274 24 300 42 104 53

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