Company Overview

For personal use only IHL-216A TBI animal model study results Study 1 Rat controlled cortical impact model Represents severe TBI Proportion of rats that reached the 0.8 0.6 0.3 0.1 I Uninjured Vehicle CBD Isoflurane IHL-216A IHL-216A restored the spatial learning and memory deficit that occurs with TBI as assessed using the Morris water maze. The effect of IHL-216A was greater than either CBD or isoflurane monotherapy. Incannex Reduction in Iba1/mm² relative to 0.90 0.80 0.70 0.60 0.50 0.40 0.30 0.20 0.10 0.00 Uninjured CBD Isoflurane IHL-216A IHL-216 reduced neuroinflammation, assessed by determining levels of the neuroinflammatory marker Iba1 relative to the vehicle treated group, to a greater extent than either CBD or isoflurane monotherapy. IHL-216A also restored the motor deficit and reduced neuronal cell death in rodents with TBI. These effects were greater than those observed with CBD and isoflurane monotherapies. Study 2 Rat sports concussion model Represents mild TBI 0.5 0.4 .. Uninjured Vehicle CBD 0.3 0.2 0.1 0.0 Iso IHL-216A Lead Assets ●●●●●00000 IHL-216A restored the spatial memory deficit that occurs with mTBI as assessed using the Y-maze. CBD only partially restored the deficit and isoflurane had no effect. This model was developed by TBI researchers in collaboration with the NFL and NFLPA to accurately represent the types of TBI that occur during contact sports, Investor Presentation 25

View entire presentation