Akouos IPO Presentation Deck
Multi-Dose Tropism Study in Cynomolgus Macaque Showed
Efficient Inner Hair Cell Transduction at Three Weeks
18
Percentage of Inner Hair Cells Expressing GFP Three Weeks
Following Administration of an AAVAnc80 Vector Encoding GFP
100
Inner Hair Cell
Transduction (%)
80
60
40
20
0
Dose
2.4E11 vg
6.0E10 vg
71.5E10 vg
0.06 0.5
4
Cochlear Frequency
Position (kHz)
32
OHCS = outer hair cells; IHCS = inner hair cells; SC = supporting cells
6.0E10 vg 2.4E11 vg
1.5E10 vg
AAVAnc80-GFP Expression in Cynomolgus Macaque Cochlea Across
Frequencies and Doses (in Vector Genomes (vg) per Cochlea)
4 kHz
32 kHz
0.125 kHz
SC
OHC
IHC
AKOUOS
75-100% of inner hair cells (IHCS) express transgene at 6E10 vg/ cochlea in the cynomolgus macaque
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