uBiome Start Up Pitch Deck

Analytic Specification Sensitivity Specificity Accuracy Intra-run Agreement (Precision) Inter-run Agreement (Precision) Reportable Range Reference Range Limit of Detection Cross-contamination uBiome Wet Lab Validation Samples 45 45 129 21 159 177 807 24 96 Sample types Stool samples which are positive and negative for pathogenic taxa Stool samples which are positive and negative for pathogenic taxa Stool samples which are positive and negative for pathogenic taxa. Standard stool sample spiked with sDNA Standard stool samples. Stool samples from 53 donors Stool samples from 55 donors plus 18 positive E. coli controls Samples from 807 self-reported healthy individuals SDNA mock communities of 28 targets at known abundance 19 samples with one sDNA each plus 77 blanks Validation Results 100.00% 100.00% 100.00% 100.00% genera, 100.00 % species 97.16% genera, 97.16% species Positive/Negative Low/Normal/High Negative or Normal 0.03% average abundance 75 reads per taxa Acceptance Criteria > 95.00% > 95.00% > 95.00% > 95.00%, > 95.00% > 95.00%, > 95.00% (Qualitative) N/A N/A N/A Status Pass Pass Pass Pass Pass Completed Completed Completed Completed Privileged and Confidential

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