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PheWAS: Breadth of Phenotyping Elucidates Critical Disease Drivers 23andMe runs GWAS in >1,000 phenotypes PheWAS (Phenome-Wide Association Study) captures pleiotropic effects of genetic variants and points to possible unwanted toxicities or potential indication expansions OR [95% CI] 0.650.725 0.8 0.8750.95 1 eosinophilic_esophagitis any_asthma rhinitis TSLP PheWAS - - + eczema psoriasis crohns ulcerative colitis multiple sclerosis - LE psoriatic_arthritis hashimotos T1D ● ● ● We observe a clear genetic signal linking TSLP to asthma We do not observe signals in phenotypes that would point to safety issues Amgen clinical trials of anti-TSLP mAb as eczema target failed. We do not observe a statistically significant genetic signal linking TSLP to eczema We observe a strong genetic signal linking TSLP to eosinophilic esophagitis → potential indication expansion in a rare disease Copyright © 2024 23and Me, Inc. 23andMe 10

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