BioNTech Investor Day Presentation Deck
Exploiting the mutanome for personalized mRNA vaccination
mRNA delivers genetic information to APCs
5 Cap 5'UTR
mRNA Nanoparticle
Formulation
Vaccine mRNA
IIIAAAA
3'UTR Poly(A) tail
viral
antigen
↑
In vitro
Synthesis
Antigen-coding sequence
AAAA
O
DNA template
RNA
Protection from
Degradation by
extracellular
RNAses
Uptake by
endocytosis
Cytoplasmic
translocation
Ribosome
Intracellular
mRNA decay
RNases
Vormehr et al., Curr Opin Immunol 39:14-22 (2016).
Immune response
Translation
Protein
Vaccine antigen
Outer space
Cytoplasm
Protein
release
Protein
Uptake of
exogenous
protein
MHC class I
epitope processing
MHC
class!
Endoplasmic reticulum
MHC class
epitope processing
MHC
classi
ECCE
Golgi
MHC
class II
Presentation of
protein-derived
epitopes
μμ
MHC
class II
Proteasome
Mutations are prevalent across different cancer indications
Expressed nsSNVs
10000-
1000-
100-
10-
kin
Lung (smoker)
Bladder
Esophagus
Colorectal (MSI-H)
Stomach
Head and neck
Cervix
B-cell lymphoma
.
Lung (non-smoker)
.
Liver
Glioblastoma
Kidney (papillary)
Kidney (clear cell)
Colorectal (MSI-L/MSS)
Uterus (carcinosarcoma)
Pancreas
|||||||
Breast
Target discovery
Prostate
Ovarian
Adrenocortical
Thyroid
BIONTECH
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