Orthofix Investor Presentation Deck

Transaction Summary Transaction Structure Leadership Headquarters Timing & Approvals ● ● ● ● ● All-stock merger of equals: SeaSpine shareholders receive 0.4163 shares of Orthofix common stock per share of SeaSpine common stock Pro forma ownership: Approximately 56.5% Orthofix / Approximately 43.5% SeaSpine 9-member board of directors 5 designated by Orthofix including Lead Independent Director - 4 designated by SeaSpine Executive Chairman: Jon Serbousek, President & CEO, Orthofix Chief Executive Officer and board member: Keith Valentine, President & CEO, SeaSpine Combined company will be headquartered in Lewisville, Texas and will retain primary offices in Carlsbad, CA, and in Verona, Italy Current facilities in Irvine, CA, Toronto, Canada, Sunnyvale, CA, Wayne, PA, Olive Branch, MS, Maidenhead UK, Munich, Germany, Paris, France and Sao Paulo, Brazil will be retained. ORTHOFIX® SeaSpine. Expected transaction close in first quarter of 2023 Subject to approval by both companies' shareholders & customary closing conditions & regulatory approvals clumz 6

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